One of the most common questions from patients I hear is what can I do to prevent skin cancer and skin aging besides sun screens? There are so many anti-aging creams that promise to treat wrinkles and aging skin. Do these creams sold at stores really work? Are prescription creams better? What is the real science behind all these creams? What are the myths behind all of the beauty skin care creams?
One myth is that of anti-oxidant creams. Vitamin C creams, vitamin E, green tea, and a host of berries and other compunds are all touted as anti-aging, anti-cancer agents. This concept of anti-oxidants quenching free radicals caused by sunlight that results in cellular damage may have a theoretical basis but has not translated into significant skin improvement when used as the sole active agent. The main argument against these anti-oxidant creams is that there are not good clinical studies showing their effectiveness. Similarly oral anti-oxidant vitamins have been shown that they do not work on preventing cancer or aging in large controlled studies. Many large studies have shown that taking beta-carotene, vitamin E or other anti-oxidant supplements or anti-oxidant creams result in no decrease in cancer or measureable aging.
Topical retinol has been touted as a wrinkle remover as good as topical prescription retinoids such as Retin A, Tazorac or generic tretinoin. The truth is that retinols do not irritate the skin like prescription retinoids nor have they been shown to improve wrinkles like prescription retinoids.
Glycolic acids and salicylic acids may cause some exfoliation but there is little proof that it causes real improvement in sun damage and wrinkles as does the prescription topical retinoids. There is good science behind these prescription retinoids but not with the other topical agents.
The other category of topical agents where scientific studies have shown skin improvement is in the area of DNA repair enzyme creams. Sunlight damages skin DNA causing cancer, wrinkles and sun damage. We all have DNA repair enzymes in our skin. As we get older we make decreased DNA repair enzymes. We can supplement our decreased DNA repair enzymes with DNA repair enzyme within liposomes made into creams . DNA repair enzyme creams have been shown to not only treat wrinkles but to repair skin DNA. There are many studies showing that DNA repair enzymes will repair the DNA in skin cells and that with liposomes they penetrate into the skin. Repairing skin DNA can lead to a decrease in pre cancerous actinic keratosis. We have completed a study using endonuclease DNA repair enzyme creams demonstrating a definite decrease in actinic actinic “>keratosis. A previous study using endonuclease DNA repair enzyme that was named Dimericine studied the effect on actinic keratosis, basal cell carcinoma and melanoma on xeroderma pigmentosum patients (patients with little DNA repair ability). The study was published in the prestigious journal, Lancet. The study showed that there was an 30 to 50% decrease in all pre-cancers and skin cancers.
Our DNA EGF Renewal contains these same DNA repair enzymes and other DNA repair enzymes in high concentrations. Our DNA EGF has been tested and used by our patients for reducing precancers, preventing skin cancers and to make the skin look younger. There is real science behind these DNA repair enzyme creams.
What is the real practical advice that I give to patients in addition to wearing sunscreens daily. Use the prescription topical retinoids like generic tretinoin cream, Retin A, Tazorac cream, Avage cream, Renova. All of these prescription creams can cause some scaling and irritation so that most patients should use these creams about two evenings per week. The other five evenings per week the DNA repair enzyme creams (DNA EGF PM and/or DNA EGF Intensive ) should be used. The use of these creams will be of great benefit for making your skin look younger and to prevent future problems with your skin.
Ronald Moy, M.D.
Professor, David Geffen School of Medicine at UCLA
421 North Rodeo Drive
Beverly Hills. Calif. (Starting in November)